Combatting Disorders of Adaptive Immunity with Systems Medicine

COSMIC represent a European consortium with 10 Beneficiaries and 7 Partner Organisations (including 5 componies) from 9 countries, and is coordinated by Antoine van Kampen together with dr. Jeroen Guikema. In the project 14 PhD students have been hired. Rodrigo Garcia Valiente works at the Bioinformatics Laboratory. COSMIC was granted in 2017 and will end in 2022.

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COSMIC Scientific Aims

COSMIC establishes state-of-the art experimental and computational approaches to elucidate the cellular and molecular mechanisms that control  the normal germinal centre reaction and its role in B-cell lymphoma (BCL; WP3) and rheumatoid arthritis (RA; WP4). Computational disease models (WP5) will be developed to complement and guide the experimental work. Through the combination of these approaches we also aim at the identification of putative diagnostic markers and/or drug targets for BCL and RA. COSMIC established a unique cross-fertilization between the oncology and auto-immunity research fields.

Rodrigo Garcia Valiente focuses on the computational modelling of the germinal center using an Agent-based model to get a better understading of its role in reumatoid arthritis. In addition, he works on the analysis of (ACPA) Adaptive Immune Receptor Repertoire sequencing (AIRR-seq). One aim is to combine the computational modelling and repertoire sequencing to enhance the interpretation of the AIRR-seq data.

Project coordination

Prof. dr. A.H.C. van Kampen (Antoine)
Bioinformatics Laboratory
P: +31 20 5667096

Project management:
Dr. Laurian Jongejan
Department of Experimental Immunology
P: +31 20 5666819

The Netherlands
Academic Medical Center, University of Amsterdam

Marie Skłodowska-Curie Actions

The Marie Skłodowska-Curie actions (MSCA), named after the double Nobel Prize winning Polish-French scientist famed for her work on radioactivity, support researchers at all stages of their careers. One type of action is the European Training Network (ETN) aimed at joint research training by partners from academia, industry, and other organisation. ETNs facilitate the the researcher to experience different sectors and develop their transferable skills by working on joint research projects.


COSMIC is a European Training Network funded from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 765158.